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Updated: Oct 2, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Successful catheter intervention for acute coronary syndrome in a patient with antiphospholipid syndrome
T Harada1, F Nakamura, Y Ikeda
1Department of Cardiovascular Medicine, University of Tokyo, Japan.
Insights
Antiphospholipid syndrome (APS) can cause coronary events. This case study shows successful coronary intervention for acute coronary syndrome in an APS patient by carefully managing blood clotting.
Area of Science:
- Cardiology
- Immunology
- Hematology
Background:
- Antiphospholipid syndrome (APS) is characterized by systemic vascular thrombosis.
- Coronary events are rare but documented manifestations of APS.
- Previous interventions like coronary angioplasty and bypass grafting in APS patients often failed due to thrombosis.
Observation:
- A patient with Antiphospholipid syndrome (APS) presented with acute coronary syndrome.
- The patient required urgent coronary intervention.
Findings:
- Successful coronary intervention was achieved in the APS patient.
- Management involved a strictly controlled coagulation state to prevent thrombosis.
- This approach mitigated the high risk of thrombotic complications associated with APS.
Implications:
- This case highlights a viable strategy for managing acute coronary syndromes in APS patients.
- Strict coagulation control can enable successful revascularization in APS.
- Further research into optimized anticoagulation protocols for APS interventions is warranted.
Abstract:
Antiphospholipid syndrome (APS) has the clinical manifestations of systemic vascular thrombotic disorders. Although coronary events are infrequent, they have been described. Early coronary interventions and vein graft bypass frequently failed because of thrombosis. Here we present a case of successful coronary intervention and management of acute coronary syndrome under a strictly controlled coagulation state in an APS patient.
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