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Caught in the act: how ATP binding triggers cooperative conformational changes in a molecular machine
1Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA.
Molecular Cell
|January 24, 2002
Abstract:
A paper recently published in Cell describes ATP-triggered conformational changes in the GroEL folding machine deciphered by use of cryo-electron microscopy, molecular engineering, and X-ray crystallographic data. Mechanistically crucial allosteric effects of ATP binding arise from rearrangement of interdomain electrostatic contacts.