Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet-activating factor, a molecular sensor for cellular damage, activates systemic immune suppression.

Jeffrey P Walterscheid1, Stephen E Ullrich, Dat X Nghiem

  • 1Department of Immunology, The University of Texas, M.D. Anderson Cancer Center, and the Graduate School of Biomedical Sciences, Houston, Texas 77030-4009, USA.

The Journal of Experimental Medicine
|January 24, 2002
PubMed
Summary

Platelet-activating factor (PAF) initiates ultraviolet (UV) radiation-induced immune suppression, a key factor in skin cancer. Blocking the PAF receptor prevents UV-induced immune suppression, revealing a novel therapeutic target.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling.

eLife·2026
Same author

Comprehensive LC-MS-MS analysis of THC isomers, analogs, homologs, and metabolites in blood and urine.

Journal of analytical toxicology·2025
Same author

LC-MS-MS confirmation of 11-nor-9-carboxy-tetrahydrocannabinol (Δ8, Δ9, Δ10) and hexahydrocannabinol metabolites in authentic urine specimens.

Journal of analytical toxicology·2024
Same author

Synthetic cannabinoid identification in cases associated with blue lotus and valerian root vaping products.

Journal of analytical toxicology·2024
Same author

Modification of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method targeting lysergic acid diethylamide (LSD) and its primary metabolite (OH-LSD) to include nine LSD analogs.

Journal of forensic sciences·2024
Same author

Cross-reactivity of 24 cannabinoids and metabolites in blood using the Immunalysis Cannabinoids Direct enzyme-linked immunosorbent assay.

Journal of analytical toxicology·2024

Area of Science:

  • Immunology
  • Dermatology
  • Molecular Biology

Background:

  • Ultraviolet (UV) radiation is a primary cause of nonmelanoma skin cancer.
  • UV-induced immune suppression is a significant risk factor for skin cancer.
  • Previous studies identified a cytokine cascade (prostaglandin E2, interleukin-4, and interleukin-10) in UV-induced immune suppression, but early molecular events remain unclear.

Purpose of the Study:

  • To investigate the role of platelet-activating factor (PAF) in the early molecular events of UV-induced immune suppression.
  • To determine if UV-induced PAF activates cytokine production and initiates immune suppression.

Main Methods:

  • UV and PAF activation of cyclooxygenase-2 (COX-2) and IL-10 reporter gene transcription were measured.
  • The in vivo effects of PAF on delayed-type hypersensitivity (DTH) were assessed.

Related Experiment Videos

  • The impact of PAF receptor antagonists on UV-induced immune suppression in mice was evaluated.

    • Main Results:

    • Both UV radiation and PAF activated COX-2 and IL-10 reporter gene transcription.
    • PAF administration mimicked UV radiation's immunosuppressive effects in vivo.
    • Injection of PAF receptor antagonists blocked UV-induced immune suppression in mice.

    Conclusions:

    • Platelet-activating factor (PAF) plays a critical role in initiating UV-induced immune suppression.
    • The PAF receptor may act as a sensor for cellular damage, triggering cytokine production and systemic immune suppression.
    • Targeting the PAF receptor presents a potential therapeutic strategy to prevent UV-induced skin cancer.