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A species comparison of 2,4-dinitrotoluene metabolism in vitro

R D Short, J C Dacre, C C Lee

Experientia

|December 15, 1979

Abstract:

Postmitochondrial supernatants prepared from livers of mice, rats, rabbits, dogs, and monkeys metabolized 2,4-dinitrotulene. The pattern of metabolites was characterized in both sexes of the species examined. In addition, the pattern of metabolites was altered by varying incubation conditions and pretreating male rats with phenobarbital or SKF 525-A.

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