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Updated: Aug 2, 2026

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
Published on: October 3, 2012
FADD: A link between TNF family receptors and caspases in Parkinson's disease
A Hartmann1, A Mouatt-Prigent, B A Faucheux
1Institut National de la Santé et de la Recherche Médicale U 289, Hôpital de la Salpêtière, Paris, France.
Abstract:
Fas-associating protein with a death domain (FADD) is a proximal adaptor protein of the tumor necrosis factor (TNF) receptor family death pathway. This human postmortem study showed a significant decrease in the percentage of FADD-immunoreactive dopaminergic (DA) neurons in the substantia nigra pars compacta of patients with PD compared with controls (-24.8%). This decrease correlated with the known selective vulnerability of nigral DA neurons in PD, suggesting that this pathway contributes to the susceptibility of DA neurons in PD to TNF-mediated apoptosis.
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