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MTR discloses subtle changes in the normal-appearing tissue from relatives of patients with MS
Malgorzata Siger-Zajdel1, Massimo Filippi, Krzysztof Selmaj
1Department of Neurology, Medical Academy of Lodz, Poland.
Neurology
|January 24, 2002
Abstract:
The presence of normal-appearing brain tissue (NABT) changes was investigated in 30 first-degree relatives of patients with MS, using magnetization transfer ratio (MTR) histograms. When compared with controls, relatives of patients with familial (p = 0.01) and sporadic (p = 0.01) MS had lower NABT MTR histogram peak heights. This study suggests a reduction of truly normal NABT in asymptomatic relatives of patients with MS.