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Three cases with TT virus infection and idiopathic neonatal hepatitis

H Tajiri1, T Tanaka, A Sawada

  • 1Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan. tajiri@ped.med.osaka-u.ac.jp

Intervirology
|January 24, 2002
PubMed

Insights

This study suggests Torque teno virus (TTV) infection may contribute to neonatal cholestasis in some infants. Gammaglobulin therapy showed promise in treating these TTV-infected cases.

Area of Science:

  • Hepatology
  • Virology
  • Neonatology

Background:

  • Idiopathic neonatal hepatitis is a significant cause of prolonged cholestasis in infants.
  • Intrahepatic fatty degeneration can be a feature of neonatal hepatitis.
  • Torque teno virus (TTV) is a common, yet often asymptomatic, human virus.

Observation:

  • Three infants with idiopathic neonatal hepatitis and fatty liver changes presented with prolonged cholestasis.
  • All patients showed immediate improvement in cholestasis following high-dose intravenous gammaglobulin therapy.
  • TTV DNA was detected in serum, duodenal fluid, and liver tissue of the affected infants.

Findings:

  • Sequence analysis confirmed identical TTV strains in serum, duodenal fluid, and liver tissue within individual patients.
  • Maternal TTV strains were nearly identical to those found in two of the infants, suggesting vertical transmission.
  • These findings indicate TTV infection as a potential contributing factor to neonatal cholestasis.

Implications:

  • This research identifies a potential subset of idiopathic neonatal hepatitis cases linked to TTV infection.
  • Gammaglobulin therapy may be a beneficial treatment for TTV-associated neonatal cholestasis.
  • Further investigation into TTV's role in neonatal liver disease is warranted.

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