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Concentration of clindamycin in human bone
Antimicrobial Agents and Chemotherapy
|August 1, 1975
Summary
Clindamycin antibiotic levels were measured in hip replacement patients. Bone concentrations were found to be 40% of serum concentrations during surgery.
Area of Science:
- Orthopedic Surgery
- Pharmacokinetics
- Infectious Disease
Background:
- Total hip replacement (THR) is a common orthopedic procedure.
- Surgical site infections (SSIs) are a potential complication following THR.
- Antibiotic prophylaxis is crucial in preventing SSIs.
Purpose of the Study:
- To determine clindamycin concentrations in serum and bone during total hip replacement surgery.
- To evaluate the bone-to-serum ratio of clindamycin in patients undergoing THR.
Main Methods:
- Thirty patients undergoing total hip replacement were enrolled.
- Clindamycin was administered preoperatively.
- Serum and bone concentrations of clindamycin were measured during surgery.
Main Results:
- Mean serum clindamycin concentration was 7.33 +/- 3.37 mug/ml.
- Mean bone clindamycin concentration was 2.63 +/- 1.76 mug/g.
- The mean bone-to-serum concentration ratio was 0.40 +/- 0.30.
Conclusions:
- Clindamycin achieves measurable concentrations in bone tissue during total hip replacement.
- The bone-penetrating ability of clindamycin in this context warrants further investigation for optimal SSI prophylaxis.