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Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Structure of Cardiac Muscles01:13

Structure of Cardiac Muscles

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Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Development of the Heart01:27

Development of the Heart

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The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
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Correction: c-kit Haploinsufficiency impairs adult cardiac stem cell growth, myogenicity and myocardial regeneration.

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Statins Stimulate New Myocyte Formation After Myocardial Infarction by Activating Growth and Differentiation of the Endogenous Cardiac Stem Cells.

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Related Experiment Video

Updated: May 2, 2026

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair
06:37

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Published on: February 3, 2017

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Myocyte renewal and ventricular remodelling.

Piero Anversa1, Bernardo Nadal-Ginard

  • 1Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, New York 10595, USA. piero_anversa@nymc.edu

Nature
|January 24, 2002
PubMed
Summary

Myocyte regeneration, driven by cardiac stem cells, offers a potential pathway to renew the adult myocardium. These cells may hold the key to repairing heart damage after infarction, promoting cardiac health.

Area of Science:

  • Cardiovascular Biology
  • Regenerative Medicine
  • Cardiac Physiology

Background:

  • The adult myocardium was traditionally considered to have limited regenerative capacity.
  • Maintaining cardiac function and youthfulness is a significant health goal.
  • Understanding myocardial renewal is crucial for treating heart disease.

Purpose of the Study:

  • To explore the potential of myocyte regeneration in the adult heart.
  • To investigate the role of multipotent cardiac stem cells in myocardial renewal.
  • To assess the feasibility of using stem cells for cardiac repair post-infarction.

Main Methods:

  • Investigating the concept of continuous cell renewal in the adult myocardium.
  • Identifying and characterizing multipotent cardiac stem cells.

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  • Exploring conditions to stimulate cardiac stem cell activity for repair.

    • Main Results:

    • Evidence suggests that myocyte regeneration is possible in the adult heart.
    • Multipotent cardiac stem cells demonstrate potential for myocardial renewal.
    • These stem cells can be induced to repair cardiac tissue after infarction.

    Conclusions:

    • Myocyte regeneration presents a novel mechanism for maintaining cardiac youthfulness.
    • Cardiac stem cells offer a promising therapeutic target for myocardial regeneration.
    • The potential exists to repair the 'broken heart' using endogenous regenerative processes.