Related Experiment Video
Updated: Jul 31, 2026
10:56
Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation
Published on: July 23, 2014
Cardiac valve replacement with mitral homograft
D B Doty1, J R Doty, J H Flores
1Department of Surgery, LDS Hospital, Salt Lake City, UT, USA.
Seminars in Thoracic and Cardiovascular Surgery
|January 24, 2002
Summary
Mitral valve homograft replacement is safe but has a high early explant rate. This cardiac valve replacement is best for young patients avoiding anticoagulants or those with resistant infections.
Area of Science:
- Cardiology
- Cardiac Surgery
- Biomaterials in Medicine
Background:
- Mitral and tricuspid valve disease necessitates surgical intervention.
- Homografts are an alternative to mechanical or bioprosthetic valves.
- Previous studies show variable outcomes for homograft valve replacement.
Purpose of the Study:
- To review the outcomes of mitral and tricuspid valve replacement using mitral valve homografts.
- To evaluate the safety and efficacy of homograft cardiac valve replacement.
- To identify patient populations most suitable for homograft valve use.
Main Methods:
- Retrospective review of 20 patients undergoing 22 cardiac valve replacements with mitral valve homografts.
- Specific surgical techniques for mitral and tricuspid valve replacement detailed.
- Intraoperative echocardiography used for accuracy confirmation.
- Concomitant Maze III procedure performed in 3 patients.
Main Results:
- All 20 patients survived the operation and are alive at follow-up (up to 3.25 years).
- Five mitral homografts (25%) and one tricuspid homograft required explantation within the first year.
- Patients demonstrated good exercise capacity (NYHA class I).
Conclusions:
- Cardiac valve replacement with mitral valve homograft can be performed safely.
- A high early explant rate indicates potential long-term competency issues.
- Homograft use should be considered for young patients avoiding anticoagulation or those with resistant infections.
Related Concept Videos
01:27Mitral Valve Prolapse I: Introduction
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
01:22Mitral Valve Prolapse II: Assessment and Management
IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular tachycardia.
01:20Mitral Regurgitation I: Introduction
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
01:25Mitral Regurgitation III: Medical Management
Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
01:22Mitral Stenosis I: Introduction
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
01:26Mitral Stenosis III: Medical Management
Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...