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Related Experiment Videos

[Relationship between prothrombin time international normalized ratio and thrombo test (%)].

Y Numata1, Y Ogata, K Arao

  • 1Department of Cardiology, Japanese Red Cross Kumamoto Hospital, Nagamineminami 2-1-1, Kumamoto, Kumamoto 862-8520.

Journal of Cardiology
|January 25, 2002
PubMed
Summary

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A power series function best describes the relationship between the prothrombin time international normalized ratio (PT-INR) and the Thrombo Test (TT) for monitoring warfarin therapy. This finding aids in standardizing anticoagulation monitoring across different laboratory methods.

Area of Science:

  • Clinical Chemistry
  • Pharmacology
  • Medical Laboratory Science

Background:

  • The prothrombin time international normalized ratio (PT-INR) is the standard for monitoring oral anticoagulant therapy.
  • The Thrombo Test (TT) is an alternative method used in Japan for anticoagulation monitoring.
  • A clear relationship between PT-INR and TT (%) has not been established.

Purpose of the Study:

  • To investigate and define the mathematical relationship between PT-INR and TT (%) in patients on warfarin therapy.
  • To identify the most suitable regression model for correlating PT-INR and TT (%) measurements.

Main Methods:

  • Simultaneous measurement of PT-INR and TT (%) in 505 patient samples.
  • Analysis using 14 different regression functions, including power series and polynomial models.

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  • Validation of findings in two additional independent laboratories using 383 and 296 samples, respectively.

    • Main Results:

    • The power series function demonstrated the highest statistical significance (p < 0.0001) and adjusted R2 (0.858).
    • The derived regression formula was TT (%) = e4.48 (PT-INR)-2.09.
    • Consistent results were observed across all three laboratories, confirming the robustness of the power series model.

    Conclusions:

    • A power series function is the most appropriate model for expressing the relationship between PT-INR and TT (%).
    • The established function is primarily influenced by the correlation between TT (%) and Thrombo Test (seconds).
    • Both internal and external validation confirm the reliability of the derived PT-INR and TT (%) relationship.