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[Impaired cardiovascular system in patients with HIV-infection and manifested cytomegalovirus infection]

P G Filippov, V I Shakhil'dian, N D Iushchuk

    Terapevticheskii Arkhiv
    |January 25, 2002
    PubMed

    Insights

    Cytomegalovirus (CMV) infection significantly impacts cardiovascular health in HIV patients, leading to cardiac muscle damage. Early treatment with cimeven improved cardiac function, highlighting the link between CMV and cardiovascular disease.

    Area of Science:

    • Cardiology
    • Infectious Diseases
    • Virology

    Context:

    • Human Immunodeficiency Virus (HIV) infection is often associated with opportunistic infections.
    • Cytomegalovirus (CMV) is a common opportunistic pathogen in immunocompromised individuals, including those with HIV.
    • The cardiovascular implications of CMV infection in HIV patients require thorough investigation.

    Purpose:

    • To evaluate the cardiovascular system's condition in HIV-infected patients experiencing active cytomegalovirus (CMV) infection.
    • To understand the relationship between manifest CMV infection and cardiovascular system impairment.

    Summary:

    • A study involving 21 HIV-infected patients with active CMV infection assessed cardiovascular health using clinical, electrocardiographic, echocardiographic, histological, and cardiospecific enzyme activity measurements.
    • Results indicated that CMV infection negatively affects cardiac muscle, causing cavity dilation, increased myocardial mass, and reduced contractility, suggesting CMV's role in dilated cardiomyopathy.
    • Treatment with cimeven demonstrated a positive impact on the myocardium's morphofunctional characteristics.

    Impact:

    • Establishes a direct correlation between the development of manifest CMV infection and cardiovascular system damage in HIV patients.
    • Provides evidence for CMV's contribution to dilated cardiomyopathy in this population.
    • Suggests that therapeutic interventions like cimeven can ameliorate cardiovascular complications associated with CMV in HIV.
    Abstract

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