Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bridging case-control studies and randomized trials.

Frits R Rosendaal1

  • 1Leiden University Medical Center (LUMC), Department of Clinical Epidemiology, C0-P, PO Box 9600, 2300 RC Leiden, The Netherlands. rosendaal@mail.medfac.leidenuniv.nl

Current Controlled Trials in Cardiovascular Medicine
|January 25, 2002
PubMed
Summary

Randomized trials and observational studies, like case-control studies, can complement each other. Case-control studies inform future randomized trials, especially for etiological research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Current and future therapeutic options for COVID-19].

Nederlands tijdschrift voor geneeskunde·2022
Same author

Change in Hematoma Size after Dexamethasone Therapy in Chronic Subdural Hematoma Subtypes: A Prospective Study in Symptomatic Patients.

Journal of neurotrauma·2022
Same author

Reference intervals of urinary kidney injury biomarkers for middle-aged men and women determined by quantitative protein mass spectrometry.

Annals of clinical biochemistry·2022
Same author

Opioid prescribing patterns after arthroplasty of the knee and hip: a Dutch nationwide cohort study from 2013 to 2018.

Acta orthopaedica·2022
Same author

Valid Evidence for Diagnosis and Treatment of Infections in the Intensive Care Unit: Beyond Randomized Control Trial Study Design (Trial Emulation and Machine Learning).

Journal of clinical medicine·2022
Same author

Association between prescription opioid use and unplanned intensive care unit admission and mortality in the adult population of the Netherlands: a registry study.

British journal of anaesthesia·2022

Area of Science:

  • Epidemiology
  • Clinical Research Methodology

Background:

  • Randomized trials and observational studies are often contrasted.
  • Different study designs can yield complementary findings.

Purpose of the Study:

  • To discuss the distinct roles of randomization and observation in research.
  • To identify conditions favoring one design over another.

Main Methods:

  • Commentary discussing the principles of randomized and observational study designs.
  • Analysis of when each design is most appropriate.

Main Results:

  • Randomization effectively addresses confounding by indication, making it ideal for therapeutic trials.
  • Case-control studies are preferred when confounding by indication is not a concern, such as in etiological or side-effect research.

Related Experiment Videos

Conclusions:

  • Study design choice depends on the research question and potential for bias.
  • Integrating insights from both randomized and observational studies enhances etiological understanding.