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Therapeutic angiogenesis for cardiovascular disease
Yin-Shan Ng1, Patricia A D'Amore
1Schepens Eye Research Institute, Departments of Ophthalmology and Pathology, Harvard Medical School, Boston, Massachusetts, USA. pdamore@vision.eri.harvard.edu
Current Controlled Trials in Cardiovascular Medicine
|January 25, 2002
Summary
Therapeutic angiogenesis using growth factors shows promise for ischemic diseases. Understanding vessel growth complexity is key for next-generation therapies.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Regenerative Medicine
Background:
- Vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) have spurred interest in therapeutic angiogenesis.
- Animal studies and clinical trials suggest potential for treating ischemic diseases.
Purpose of the Study:
- To explore the potential of growth factors in inducing therapeutic angiogenesis.
- To reconsider the complexity of therapeutic angiogenesis based on new biological insights.
Main Methods:
- Review of animal studies and clinical trials on therapeutic angiogenesis.
- Analysis of the cellular and molecular biology of vessel growth.
Main Results:
- Therapeutic angiogenesis holds promise for treating ischemic diseases.
- The complexity of stable vessel formation is increasingly recognized.
Conclusions:
- Insights into the multistep process of vessel formation are crucial.
- Understanding complexity will guide the development of advanced angiogenesis therapies.