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Evolution of the initiating enzymes of the complement system
Masaru Nonaka1, Seita Miyazawa
1Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Tokyo 113-0033, Japan. mnonaka@biol.s.u-tokyo.ac.jp
Genome Biology
|January 25, 2002
Abstract:
Analysis of the human MASP-1/3 gene, which encodes two proteases of the lectin-triggered complement cascade, has revealed alternatively used serine-protease-encoding regions for the gene's two protein products. Phylogenetic studies indicate that one arose by retrotransposition early in vertebrate evolution, supporting the idea that the lectin branch of the complement cascade arose earlier than the 'classical' pathway.