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Family-based tests of association and/or linkage
1Department of Applied Statistics, University of Reading, UK. j.whittaker@ic.ac.uk
Annals of Human Genetics
|January 25, 2002
Abstract:
The large literature on family-based tests of association and/or linkage is reviewed, concentrating on the underlying principles and on recent methodological developments. We explain the distinction between testing for association and testing for linkage, and give our views on the circumstances in which each is the appropriate null hypothesis.