Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Surgical "placebo" controls.

Robert Tenery1, Herbert Rakatansky, Frank A Riddick

  • 1Council on Ethical and Judicial Affairs of the American Medical Association, Chicago, Illinois 60610, USA.

Annals of Surgery
|January 25, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prostaglandin Administration and Outcomes in Children on Extracorporeal Membrane Oxygenation.

World journal for pediatric & congenital heart surgery·2026
Same author

A heterobifunctional IRAK4-targeting degrader impairs myddosome signaling in acute kidney injury and ameliorates kidney fibrosis.

Communications biology·2026
Same author

Machine learning-based clustering differentiates bilateral hepatocellular carcinoma characteristics and prognosis.

Surgery·2026
Same author

The combination of a cancer vaccine, pembrolizumab, and stereotactic body radiation in patients with locally advanced pancreatic cancer: a single-arm, phase II study.

Nature communications·2026
Same author

Understanding the Patient Perspective: A Scoping Review of Communication Preferences in Surgical Oncology.

Journal of surgical oncology·2026
Same author

Perioperative changes in ALBI and platelets (CAP): association with postoperative complications among patients undergoing surgery for hepatocellular carcinoma.

HPB : the official journal of the International Hepato Pancreato Biliary Association·2025

Ethical guidelines for surgical placebo controls in trials recommend their limited use for new procedures on untreatable diseases. Rigorous informed consent and risk-benefit analysis are essential when employing these controls.

Area of Science:

  • Medical Ethics
  • Surgical Research
  • Clinical Trial Design

Background:

  • Ethical concerns surround surgical trials using placebo controls where interventions are omitted.
  • Existing guidelines for drug placebos do not adequately address surgical placebo controls.

Purpose of the Study:

  • To establish ethical guidelines for the use of surgical placebo controls in surgical trials.
  • To address the ethical considerations specific to surgical placebo interventions.

Main Methods:

  • Developed ethical guidelines through extensive literature review.
  • Consulted with experts in surgical ethics and clinical research.

Main Results:

  • Surgical placebo controls are appropriate for novel procedures targeting diseases without other surgical options, especially if placebo effects are likely.

Related Experiment Videos

  • Standard, effective non-surgical treatments must be offered if available and acceptable to patients.

    • Conclusions:

    • Surgical placebo controls should be reserved for situations where no alternative trial design can provide necessary data.
    • Use of surgical placebo controls requires stringent informed consent and thorough risk-benefit assessment.
    • Guidelines adopted by the American Medical Association (AMA) now include these ethical considerations.