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Clinical experience with a mobile ocular perfusion pump.

R A Ralph, M G Doane, C H Dohlman

Archives of Ophthalmology (Chicago, Ill. : 1960)

|October 1, 1975

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Continuous perfusion using a mobile pump effectively treated severe dry-eye symptoms in 12 patients. This innovative method offered significant relief, particularly after ocular surface injuries and surgeries.

Area of Science:

Ophthalmology
Biomedical Engineering

Background:

Severe dry eye disease significantly impacts patient quality of life.
Conventional treatments may be insufficient for severe cases, including those following chemical burns or reconstructive surgeries.

Purpose of the Study:

To evaluate the efficacy of continuous ocular surface fluid delivery using a mobile perfusion pump.
To assess the management of severe dry eye symptoms through constant perfusion.

Main Methods:

A mobile perfusion pump was utilized for continuous fluid delivery to the ocular surface in 12 patients.
A total of 1,500 patient-days of perfusion were recorded, with one patient using the device for 2.5 years.
Various perfusion fluids were tested, including balanced salt solution, artificial tears, acetylcysteine, and serum/plasma.

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Main Results:

Continuous perfusion ameliorated severe dry-eye symptoms in all treated patients.
The mobile pump demonstrated value in managing dry eye, especially post-chemical burns, keratoplasty, or eyelid reconstruction.

Conclusions:

Mobile perfusion pump delivery offers a valuable therapeutic option for severe dry eye.
This method provides sustained ocular surface hydration and symptom relief in challenging cases.