Related Experiment Video
Updated: Oct 2, 2026

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
Published on: May 10, 2022
Interaction of CD22 with alpha2,6-linked sialoglycoconjugates: innate recognition of self to dampen B cell
Astrid Lanoue1, Facundo D Batista, Mairi Stewart
1Laboratory of Molecular Biology, Medical Research Council, Hills Road, Cambridge CB2 2QH, GB.
Abstract:
CD22 is a glycoprotein that associates with the B cell antigen receptor and acts as a negative regulator of receptor signaling; its extracellular domain binds alpha2,6-linked sialoglycoconjugates. Here we show that B cell activation by antigen displayed on the surface of a target cell is depressed if the target co-expresses alpha2,6-sialoglycoconjugates: this inhibition is dependent on CD22. Since sialylation is largely a feature of higher eukaryotes with alpha2,6-sialyltransferase increasing during inflammation, we propose that the CD22 / sialoglycoconjugate interaction allows context-dependent B cell activation, possibly acting as a crude discriminator of self in order to dampen B cell autoreactivity and the initiation of autoimmunity.
More Related Videos
08:58Characterization of Glycoproteins with the Immunoglobulin Fold by X-Ray Crystallography and Biophysical Techniques
Published on: July 5, 2018
11:10Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
Published on: June 29, 2016
Related Concept Videos
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Antigens Involved in Adaptive Immunity
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Immunoglobulin-like Cell Adhesion Molecules
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Diversity of Antigen Receptors
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Antibody Actions
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...