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Abietic acid inhibits lipoxygenase activity
N Nuray Ulusu1, Dilek Ercil, M Koray Sakar
1Hacettepe University, Faculty of Medicine, Department of Biochemistry, 06100 Ankara, Turkey.
Phytotherapy Research : PTR
|January 25, 2002
Abstract:
In this study, it was shown that abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase (linoleate: oxygen oxidoreductase, EC 1.13.11.12) and an IC(50) of 29.5 +/- 1.29 microM was determined. Since the lipoxygenase pathway leads to the biosynthesis of leukotrienes this result supports the view that abietic acid may be used in the treatment of allergic reactions.