Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Upper GI bleeding in healthy full-term infants: a case-control study.

M Lazzaroni1, M Petrillo, R Tornaghi

  • 1Department of Gastroenterology, L. Sacco University Hospital, Milano, Italy.

The American Journal of Gastroenterology
|January 26, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Can nausea and vomiting be treated with ginger extract?

European review for medical and pharmacological sciences·2015
Same author

Sigmoid stricture in a 39-year-old female.

BMJ case reports·2011
Same author

Octatropine methyl bromide and diazepam combination (Valpinax) in patients with irritable bowel syndrome: a multicentre, randomized, placebo-controlled trial.

European review for medical and pharmacological sciences·2010
Same author

Bilateral pneumothorax and pneumomediastinum during upper endoscopy: the role of gastric perforation and of cardiopulmonary resuscitation maneuvers.

Endoscopy·2009
Same author

Missed lesions with conventional endoscopy discovered by double-balloon enteroscopy: endoscopist or instrument?

Alimentary pharmacology & therapeutics·2009
Same author

This month in the Scandinavian Journal of Gastroenterology.

Scandinavian journal of gastroenterology·2009
Same journal

Calendar of Courses, Symposiums and Conferences.

The American journal of gastroenterology·2026
Same journal

Molecular Nonendoscopic Tests for the Early Detection of Esophageal Squamous Carcinoma and High-Grade Dysplasia: Promising Progress.

The American journal of gastroenterology·2026
Same journal

ACG Clinical Guideline: Colonic Diverticulitis.

The American journal of gastroenterology·2026
Same journal

Continuing Medical Education Questions: July 2026.

The American journal of gastroenterology·2026
Same journal

Continuing Medical Education Questions: July 2026.

The American journal of gastroenterology·2026
Same journal

2026 CME Information.

The American journal of gastroenterology·2026
See all related articles

Newborn upper GI bleeding (UGIB) is linked to significant upper gastrointestinal mucosal lesions. Higher serum pepsinogen levels may indicate a risk factor for these lesions and complications in infants.

Area of Science:

  • Gastroenterology
  • Neonatology
  • Pediatric Surgery

Background:

  • Upper gastrointestinal bleeding (UGIB) in newborns is a critical condition requiring prompt diagnosis and management.
  • Understanding the specific mucosal lesions and associated risk factors is crucial for effective treatment strategies.

Purpose of the Study:

  • To determine the frequency and types of upper gastrointestinal mucosal lesions in neonates with UGIB.
  • To assess the diagnostic utility and safety of upper gastrointestinal endoscopy in this population.
  • To identify risk factors associated with UGIB in newborn infants.

Main Methods:

  • A case-control study involving 5180 infants, defining UGIB within 4 days of delivery.
  • Diagnosis was established via endoscopic examination.

Related Experiment Videos

  • Parameters analyzed included perinatal data, biochemical profiles, and serum gastrin/pepsinogen levels, compared to a control group of 53 healthy infants.

    • Main Results:

    • 1.23% of newborns experienced UGIB, with endoscopy performed in 53 cases.
    • Esophageal, gastric, and duodenal lesions were identified in 24, 43, and 1 infant, respectively.
    • Significantly higher median serum pepsinogen levels were observed in the UGIB group compared to controls.

    Conclusions:

    • Newborn UGIB frequently involves clinically significant upper GI mucosal lesions.
    • Endoscopy is a valuable diagnostic tool for identifying these lesions.
    • Elevated serum pepsinogen may serve as a significant risk factor for UGIB and its complications in neonates.