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A prolyl endopeptidase-inhibiting benzofuran dimer from Polyozellus multiflex
1Department of Agricultural Chemistry, Kyungpook National University, 1370 Sankyuk-Dong, Taegu 702-701, Korea. kssong@bh.knu.ac.kr
Journal of Natural Products
|January 26, 2002
Abstract:
A new benzofuran dimer, 5,6,5',6'-tetrahydroxy[3,3']bibenzofuranyl-2,2'-dicarboxylic acid dimethyl ester (kynapcin-24), was isolated from Polyozellus multiflex and shown to noncompetitively inhibit prolyl endopeptidase (PEP), with an IC(50) value of 1.14 microM. Kynapcin-24 was less inhibitory to other serine proteases such as chymotrypsin, trypsin, and elastase.