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Related Experiment Videos

Bone metabolism during the perimenopausal transition: a prospective study.

Vanadin Seifert-Klauss1, Judith E Mueller, Peter Luppa

  • 1Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Ismaninger Strasse 22, D-81675 Munich, Germany. vanadin.seifert-kluass@lrz.tum.de

Maturitas
|January 26, 2002
PubMed
Summary

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Bone turnover changes begin in late premenopause, with decreased bone formation potentially preceding increased resorption. N-terminal telopeptide (NTX) effectively tracks bone metabolism shifts during estrogen withdrawal.

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Menopause Research

Background:

  • Bone turnover involves continuous remodeling, influenced by hormonal changes.
  • Menopause significantly impacts bone metabolism due to estrogen decline.
  • Understanding early menopausal bone changes is crucial for skeletal health.

Purpose of the Study:

  • To track biochemical markers of bone formation and resorption over one year.
  • To compare these changes across premenopausal, perimenopausal, and early postmenopausal women.
  • To identify sensitive markers of menopausal transition-related bone metabolism shifts.

Main Methods:

  • Longitudinal study of 64 women categorized by menopausal status.
  • Measurement of bone resorption markers: pyridinoline (PYD), deoxypyridinoline (DPD), and N-terminal telopeptide (NTX).

Related Experiment Videos

  • Measurement of bone formation markers: osteocalcin (OC) and bone-specific alkaline phosphatase (BAP).
  • Statistical analysis using generalized estimating equations (GEE).

    • Main Results:

    • Bone-specific alkaline phosphatase (BAP) decreased in late premenopausal women.
    • Perimenopausal women showed significant changes in PYD, DPD, and OC, with higher NTX levels.
    • Postmenopausal women had elevated NTX, while PYD and DPD remained similar to perimenopausal levels.

    Conclusions:

    • Bone turnover alterations commence in late premenopause, with formation potentially decreasing before resorption increases.
    • N-terminal telopeptide (NTX) demonstrates sensitivity to estrogen withdrawal-induced bone metabolism changes.
    • Pyridinium cross-links (PYD, DPD) show distinct temporal changes during perimenopause but stabilize in early postmenopause.