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Evaluation of pituitary microadenomas with dynamic MR imaging
Thomas Rand1, P Lippitz, E Kink
1Department of Radiology, University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. thomas.rand@univie.ac.at
Purpose:
To evaluate the use of keyhole dynamic magnetic resonance (MR) imaging in the evaluation of women with borderline hyperprolactinemia.
Patients And Methods:
We investigated 30 patients (mean age 31.6+/-4.3 years) with moderate hyperprolactinemia and clinically suspected microadenomas on T1-weighted spin echo (SE) sequences (repetition time (TR)/echo time (TE) 625/15 ms) with keyhole dynamic imaging and contrast enhancement of the pituitary gland. The probability of lesion presence according to MR criteria was ranked on a five-grade scale and compared with standard examinations of the hypophysis before and after intravenous administration of contrast media.
Results:
The probability for lesion presence showed a trend toward lower scores on standard SE sequences and higher scores with dynamic imaging (P=0.067).
Conclusion:
Dynamic keyhole imaging of the pituitary gland could help establish a diagnosis of microadenomas with a higher probability.
Insights
Dynamic keyhole magnetic resonance (MR) imaging shows promise for diagnosing pituitary microadenomas in women with borderline hyperprolactinemia, potentially improving diagnostic accuracy.
Area of Science:
- Radiology
- Endocrinology
- Medical Imaging
Background:
- Hyperprolactinemia is a common endocrine disorder often caused by pituitary microadenomas.
- Accurate diagnosis of microadenomas is crucial for appropriate patient management.
- Standard magnetic resonance (MR) imaging may have limitations in detecting small pituitary lesions.
Purpose of the Study:
- To assess the efficacy of keyhole dynamic MR imaging in evaluating women with borderline hyperprolactinemia.
- To compare the diagnostic performance of dynamic keyhole MR imaging with standard MR techniques.
Main Methods:
- Thirty patients with moderate hyperprolactinemia and suspected microadenomas were studied.
- Keyhole dynamic contrast-enhanced MR imaging was performed on the pituitary gland.
- Lesion presence probability was ranked and compared with standard MR sequences.
Main Results:
- A trend towards lower lesion detection scores with standard sequences was observed.
- Dynamic keyhole imaging demonstrated a trend towards higher lesion detection scores (P=0.067).
Conclusions:
- Dynamic keyhole MR imaging may enhance the diagnostic probability of pituitary microadenomas.
- This technique could be a valuable tool in evaluating patients with hyperprolactinemia.