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Obesity and its potential mechanistic basis.

A M Prentice1

  • 1MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, London, UK.

British Medical Bulletin
|January 26, 2002
PubMed
Summary

Obesity is central to the thrifty phenotype and metabolic syndrome, interacting with early-life factors. Understanding obesity

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Area of Science:

  • Metabolic health and obesity research.
  • Developmental origins of health and disease (DOHaD).

Background:

  • Obesity is a primary driver of the thrifty phenotype and associated metabolic syndrome.
  • Metabolic syndrome manifestations are rare without obesity and correlate with excess fat mass.

Purpose of the Study:

  • To summarize the metabolic underpinnings of obesity.
  • To explore potential long-term programming mechanisms influencing obesity.

Main Methods:

  • Review of existing literature on obesity, thrifty phenotype, and metabolic syndrome.
  • Analysis of potential gene-environment interactions and life-course influences.

Main Results:

  • Obesity interacts with early-life programming to establish disease risk.
  • Evidence linking early diet to obesity programming is weak, potentially obscured by lifestyle factors.

Conclusions:

  • Molecular discoveries in weight regulation highlight the need for further research.
  • Comprehensive studies on gene-environment interactions and life-course influences are crucial for understanding complex phenotypes like metabolic syndrome.

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