[Influence of hypothyroidism on the lacticodehydrogenase isoenzymes during the cerebral cortex maturation in the rat]

The isoenzymes of lacticdehydrogenase of cerebral cortex, investigated by starch gel electrophoresis, are changed during pre and neonatal thyroidectomies in relation to these factors: a) dose of the drug (131I or Propylthiouracil), b) date of gestation, c) the age of the animal (with a maximal modification at the 17th-18th day). They retain an enzymatic pattern like the fetal pattern, showing the retardation of the developing central nervous system.