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A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
Published on: May 6, 2018
Radiological study of 12 high-grade surface osteosarcomas
D Vanel1, P Picci, M De Paolis
1Laboratorio di Ricerca Oncologica, Institute Rizzoli, Bologna, Italy. vanel@igr.fr
Skeletal Radiology
|January 26, 2002
Summary
High-grade surface osteosarcomas typically present as ossified masses originating from bone cortex with minimal marrow involvement. Imaging characteristics are crucial for diagnosis and staging of these rare bone tumors.
Area of Science:
- Orthopedic Oncology
- Musculoskeletal Radiology
- Bone Tumors
Background:
- High-grade surface osteosarcoma is a rare malignant bone tumor.
- Accurate diagnosis and staging are critical for effective treatment.
Purpose of the Study:
- To describe the imaging features of high-grade surface osteosarcomas.
- To correlate imaging findings with histological diagnoses.
Main Methods:
- Retrospective review of radiological examinations (plain films, CT, MRI) of 12 patients.
- Comparison of imaging findings with histopathology.
Main Results:
- Tumors were predominantly located in the femur and tibia.
- Dense ossification was a common feature, with minimal marrow involvement.
- Two cases mimicked periosteal osteosarcoma on imaging.
Conclusions:
- High-grade surface osteosarcomas characteristically show an ossified mass arising from the bone cortex.
- Minimal or no marrow involvement is typical.
- Radiological assessment aids in differentiating from other bone lesions.

