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Updated: Jul 28, 2026

Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases
Published on: February 24, 2018
Intrahepatic distribution of human glutathione-dependent formaldehyde dehydrogenase
P I Maly1, V Crotet, M Toranelli
1Institute of Anatomy, University of Basel, Pestalozzistrasse 20, 4056 Basel, Switzerland.
Abstract:
By means of a microelectrophoretic separation technique the different forms of alcohol dehydrogenase can be detected in microdissected liver tissue samples of the nanogram range. Alcohol dehydrogenase 3 (the glutathione-dependent formaldehyde dehydrogenase) was demonstrated to be zonally distributed in the human liver parenchyma. A periportal/perivenous gradient is evident in both sexes, however, the periportal/perivenous ratio is higher in males. The biological functions of this enzymatic form and the possible role of the periportal maximum are discussed.
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