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[Dialysis Outcomes and Practice Patterns Study: data on the use of central venous catheters in chronic hemodialysis]
C Combe1, R L Pisoni, F K Port
1Service de néphrologie B, Centre hospitalier universitaire de Bordeaux, France. christian.combe@chu-bordeaux.fr
Insights
Central venous catheters are frequently used for chronic hemodialysis, especially in sicker patients. However, catheter use increases infection risk and lowers survival rates compared to permanent access, necessitating careful indication.
Area of Science:
- Nephrology
- Vascular Access
- Public Health
Background:
- Central venous catheters (CVCs) are common vascular access for chronic hemodialysis.
- CVC use is influenced by clinical factors and regional practices.
- The Dialysis Outcomes and Practice Patterns Study (DOPPS) provides insights into CVC utilization.
Purpose of the Study:
- To analyze CVC use patterns in the US and Europe from DOPPS data.
- To compare CVC-associated risks with native arteriovenous fistulae and grafts.
- To evaluate the impact of CVCs on patient outcomes in chronic hemodialysis.
Main Methods:
- Observational study of over 10,000 hemodialysis patients in the US and Europe.
- Two-year follow-up period.
- Analysis of catheter use, infection rates, comorbidities, and mortality risk.
Main Results:
- CVC use is less frequent in Europe than in the US.
- Both tunneled and untunneled catheters have higher infection rates than permanent access.
- Patients with comorbidities and those starting hemodialysis with tunneled catheters face higher mortality risks.
Conclusions:
- CVCs are utilized in hemodialysis patients with significant morbidity.
- CVC use is linked to increased infection risk and reduced survival, particularly for tunneled catheters.
- Limiting CVC use to clear clinical indications is crucial for patient safety.
Abstract:
Central venous catheters are widely used as vascular accesses for chronic haemodialysis. Different factors may lead to catheter use, whether clinical such as emergency dialysis, or related to practices specific to each dialysis unit or country. The Dialysis Outcomes and Practice Patterns Study is an observational study of more than 10,000 representative patients treated by haemodialysis followed over a two-year period in the United States, Japan, and in five European countries (France, Germany, Italy, Spain, United Kingdom). DOPPS data from the United States and Europe about catheters are reported in this paper. Catheter use is less frequent in Europe than in the US, both in incident and prevalent patients, and in patients who have been seen by a nephrologist in the pre-dialysis period. Tunneled and untunneled catheters are each associated with a significantly higher frequency of access infection compared to native arteriovenous fistulae and grafts. Patients with important comorbidities such as diabetes, cardiovascular diseases, malnutrition or dementia are more likely to be dialysed with tunneled catheters. Furthermore, patients initiating hemodialysis with a tunneled catheter display higher mortality risk compared to patients starting hemodialysis with a permanent access. In summary, DOPPS data indicate that central venous catheters are used for chronic haemodialysis in patients with a high level of morbidity, and that their utilisation is associated to an additional risk, particularly of infection, and to a lower survival for tunneled catheters. Appropriate care should limit the utilisation of central venous catheters to clinically undisputable indications.
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