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[Incidence and risk factors for infections from hemodialysis catheters]
1Centre de rein artificiel, Tassin La Demi-lune. Gjean14357@aol.com
Abstract:
We report here a revue of hemodialysis catheter-related infections data published since 1985. The reported prevalence of bacteremia is 1 to 20% of catheters, and incidence is 0.72 to 9/1000 catheter-days. Local infection is reported in 6 to 63% of catheters and in 1 to 5/1000 catheter-days. Tunneled catheters and implantables chambers reported less infection rate. The most severe complication is endocarditis (4% rate). Death occurs in 8 to 20% of cases. Reported microbial data show that Staphylococcus aureus (SA) is responsible for most infections ahead of non-aureus Staphylococcus. SA skin colonisation is a risk factor for catheter colonisation and the first step of infection. On the other hand, the host immunity impairment in hemodialysis patients seems a significant risk factor. Iron overload, specially after blood transfusions, older age, diabetes mellitus, low serum albumin level, previous history of bacteremia and immunosuppressive treatment have been frequently involved. Other catheter-related factors are time of use, absence of tunnel and use for parenteral nutrition. Nurses plans, dressing type and frequency, nurses work experience are also important. In spite of recent progress in risk factor understanding, hemodialysis-related infection remains frequent. Multicentre studies are necessary to better evaluated care protocols and new catheter material.
Insights
Hemodialysis catheter infections, including bacteremia and local infections, remain frequent despite advances. Staphylococcus aureus is a primary cause, with patient immunity and catheter type being significant factors.
Area of Science:
- Nephrology
- Infectious Diseases
- Medical Device Infections
Background:
- Catheter-related infections are a significant complication in hemodialysis patients.
- Understanding risk factors is crucial for preventing serious outcomes like bacteremia and endocarditis.
Purpose of the Study:
- To review and synthesize data on hemodialysis catheter-related infections since 1985.
- To identify key microbial causes, risk factors, and complications associated with these infections.
Main Methods:
- Systematic literature review of published data on hemodialysis catheter infections.
- Analysis of reported prevalence, incidence, microbial agents, and risk factors.
Main Results:
- Bacteremia prevalence: 1-20%; incidence: 0.72-9/1000 catheter-days. Local infection prevalence: 6-63%; incidence: 1-5/1000 catheter-days.
- Staphylococcus aureus is the most common pathogen; skin colonization is a key risk factor.
- Patient factors (impaired immunity, age, diabetes, iron overload) and catheter factors (duration, type) influence infection rates. Endocarditis and death are severe complications.
Conclusions:
- Hemodialysis catheter infections persist as a major clinical challenge.
- Multicenter studies are needed to evaluate care protocols and novel catheter materials for improved infection control.
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