Related Experiment Video
Updated: Aug 10, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
[Metopic craniosynostosis, probable effect of intrauterine exposure to maternal valproate treatment]
J P Chabrolle1, B Bensouda, H Bruel
1Service de médecine néonatale, groupe hospitalier du Havre, 55bis, rue Gustave-Flaubert, 76600 Le Havre, France. jchabrolle@ch-havre-fr
Unlabelled:
Metopic craniosynostosis may be an adverse effect of valproic acid exposed fetus.
Cases:
We report two infants with metopic craniosynostosis, born to mothers who were treated with valproic acid. In one case, a prenatal diagnosis was made. In the other case, only the male dizygotic twin was affected.
Conclusion:
Trigonocephaly may be a symptom of valproate embryofoetopathy detectable by antenatal ultrasound examination.
More Related Videos
03:19Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes
Published on: June 28, 2024
08:03Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Related Concept Videos
Teratogenicity
Mitral Valve Prolapse III: Nursing Management