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Hepatitis B Seroprevalence Study 1999.

L James1, C W Fong, B H Foong

  • 1Communicable Diseases Branch, Epidemiology and Disease Control Division, Ministry of Health, Singapore. Lyn_JAMES@moh.gov.sg

Singapore Medical Journal
|January 29, 2002
PubMed
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Hepatitis B prevalence in Singapore is 4%, with only 40% immune. Young adults (18-29) show low immunity (28%), highlighting the need for enhanced hepatitis B vaccination programs.

Area of Science:

  • Public Health
  • Epidemiology
  • Infectious Diseases

Background:

  • Hepatitis B poses a significant public health challenge in Singapore.
  • Understanding seroprevalence is crucial for effective control strategies.

Purpose of the Study:

  • To determine the prevalence of Hepatitis B surface antigen (HBsAg), Hepatitis B e antigen (HBeAg), and antibodies in the Singapore population.
  • To assess age-, gender-, and ethnicity-specific seroprevalence rates.
  • To evaluate population immunity levels against Hepatitis B virus (HBV).

Main Methods:

  • A cross-sectional survey of 4,698 Singapore residents aged 18-69 years was conducted in 1999.
  • Serological markers for Hepatitis B infection and immunity were analyzed.

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Main Results:

  • The overall prevalence of HBsAg in the general population was approximately 4%.
  • About 13% of HBsAg carriers were also HBeAg positive.
  • Only 40% of the population exhibited immunity to HBV (from vaccination or prior infection).
  • A significant gap in immunity was observed in younger adults (18-29 years), with only 28% immune.

Conclusions:

  • A substantial portion of the Singapore population remains susceptible to Hepatitis B, particularly young adults.
  • Strengthening the Hepatitis B immunization program is essential to increase population immunity, especially among vulnerable age groups.