Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Automatic procedures for protein design.

A Jaramillo1, L Wernisch, S Hery

  • 1Service de Conformation de Macromolecules Biologiques, CP160/16, Universite Libre de Bruxelles, 50 av. F.D. Roosevelt, 1050, Brussels, Belgium.

Combinatorial Chemistry & High Throughput Screening
|January 29, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oral cancer knowledge in adults evaluated through a phone survey in the context of the SARS-CoV2 health emergency in Colombia.

Medicina oral, patologia oral y cirugia bucal·2023
Same author

Adipokines underlie the early origins of obesity and associated metabolic comorbidities in the offspring of women with pregestational obesity.

Biochimica et biophysica acta. Molecular basis of disease·2019
Same author

Benign differentiation of treated neuroblastoma as a cause of false positive by <sup>123</sup>I-MIBG SPECT/CT. Usefulness of <sup>18</sup>F-FDG PET/CT.

Revista espanola de medicina nuclear e imagen molecular·2019
Same author

Quantification of muscular inflammation by <sup>18</sup>F-FDG PET/CT for initial evaluation and treatment response on inflammatory myopathy: A case report.

Revista espanola de medicina nuclear e imagen molecular·2016
Same author

The value of <sup>11</sup>C-methionine PET in the early differentiation between tumour recurrence and radionecrosis in patients treated for a high-grade glioma and indeterminate MRI.

Revista espanola de medicina nuclear e imagen molecular·2016
Same author

Cervical lymph nodes from unknown primary tumour. Squamous cell carcinoma of tonsils related to papilloma human virus detected by (18)F-FDG PET/CT.

Revista espanola de medicina nuclear e imagen molecular·2015

This review explores computational methods for determining amino acid sequences that fit a specific protein structure. These techniques aid in understanding structural constraints and designing novel proteins with desired conformations.

Area of Science:

  • Biochemistry
  • Computational Biology
  • Structural Biology

Background:

  • Protein design is crucial for understanding molecular interactions and creating novel biomolecules.
  • Decades of research have yielded various computational approaches to protein sequence design.
  • Understanding the relationship between protein structure and sequence is a fundamental challenge.

Purpose of the Study:

  • To review computational procedures for deriving amino acid sequences compatible with given protein backbone structures.
  • To provide insights into the constraints imposed by protein 3D structure on sequence.
  • To guide the design of proteins with specific backbone conformations.

Main Methods:

  • Overview of diverse protein design strategies developed over the past decade.

Related Experiment Videos

  • Detailed presentation of the DESIGNER sequence selection procedure.
  • Illustration of fundamental principles in computational sequence selection.

    • Main Results:

    • Computational methods can predict amino acid sequences for specific protein backbones.
    • The DESIGNER procedure exemplifies key principles in sequence-structure compatibility.
    • Application to small proteins reveals insights into design limitations and possibilities.

    Conclusions:

    • Computational sequence derivation offers valuable insights into protein structure-sequence relationships.
    • The DESIGNER procedure highlights the potential and challenges in de novo protein design.
    • Further research is needed to refine computational design methods for broader applications.