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[Evaluation of atrial natriuretic peptide in differentiating benign and malignant pleural effusion]
Objective:
To discuss the value of atrial natriuretic peptide (ANP) in differentiating benign and malignant pleural effusion.
Methods:
Direct radioimmunoassay was used to detect ANP of pleural effusion and serum in 30 tuberculous and 26 cancerous pleural effusion patients.
Results:
The ANP in tuberculous and cancerous pleural effusion were (75 +/- 9) ng/L, (157 +/- 45) ng/L respectively, and significant difference was found (P < 0.001). The ANP of tuberculous pleural effusion was apparently lower [(75 +/- 9) ng/L] than serum [(170 +/- 37) ng/L], and significant difference was also found (P < 0.001). The ratio of ANP of pleural effusion to that of serum were 0.47 +/- 0.17, 0.99 +/- 0.46 respectively in tuberculous and cancerous pleural effusion patients. The sensitivity of ANP was 81% and specificity 100% in diagnosing malignant pleural effusion.
Conclusions:
Detecting ANP of pleural effusion is one of important methods for differentiating benign and malignant pleural effusion.