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Related Experiment Videos

Verteporfin infusion-associated pain.

Natalie Borodoker1, Richard F Spaide, Leandro Maranan

  • 1Vitreous-Retina-Macula Consultants of New York, and the LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York 10021, USA.

American Journal of Ophthalmology
|January 29, 2002
PubMed
Summary
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Oral hydration does not prevent pain during verteporfin infusions for age-related macular degeneration. Pain is an idiosyncratic reaction, with previous pain history being the only predictor for verteporfin infusion-associated pain.

Area of Science:

  • Ophthalmology
  • Pharmacology

Background:

  • Verteporfin photodynamic therapy is used for subfoveal choroidal neovascularization.
  • Infusion-associated pain is a known complication, but its incidence and predictors require further investigation.

Purpose of the Study:

  • To evaluate if oral hydration reduces verteporfin infusion-associated pain.
  • To identify other factors predisposing to this complication.

Main Methods:

  • A nonrandomized clinical trial involving 250 patients with age-related macular degeneration undergoing verteporfin therapy.
  • 125 patients received oral hydration before infusion; 125 served as controls.
  • Clinical factors were assessed for association with infusion-associated pain.

Main Results:

Related Experiment Videos

  • The incidence of verteporfin infusion-associated pain was 9.6% in both the hydration and control groups.
  • No statistically significant difference in pain incidence was observed between groups.
  • A history of pain with previous verteporfin administration was the only significant predictor of pain (P < .001).
  • Pain occurred in various locations, most commonly the back, and resolved upon infusion cessation.

Conclusions:

  • Oral hydration does not prevent verteporfin infusion-associated pain.
  • This pain appears to be an idiosyncratic drug reaction.
  • A history of prior pain is the primary predictor; other baseline characteristics are not predictive.