Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Head and neck brachytherapy.

Jean-Jacques Mazeron1, Georges Noël, Jean-Marc Simon

  • 1Centre des Tumeurs, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

Seminars in Radiation Oncology
|January 29, 2002
PubMed
Summary

Interstitial brachytherapy offers superior head and neck tumor control by delivering precise radiation doses. This method minimizes damage to surrounding tissues, reducing complications compared to external beam radiation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contribution of fluorodeoxyglucose positron-emission tomography combined with magnetic resonance imaging for differential diagnosis between radionecrosis and recurrence of treated brain metastasis.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2026
Same author

Surface-guided analysis of breast shape changes during postoperative radiotherapy by using a functional map framework.

Medical physics·2026
Same author

From relapse to survival: real-world clinical impact of a multimodal approach in first-time recurrent glioblastoma : FROST: multimodal treatment for GBM recurrence.

Journal of neuro-oncology·2026
Same author

Deciphering the mechanisms of oxygen transfer into a wine bottle.

Science advances·2026
Same author

Magnetic resonance imaging-guided radiotherapy for prostate cancer: A systematic review of the literature.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2026
Same author

Bevacizumab for Radiation-Induced (Radiculo)plexopathy.

European journal of neurology·2026

Area of Science:

  • Oncology
  • Radiation Oncology
  • Medical Physics

Background:

  • External beam irradiation for head and neck tumors often leads to significant complications in adjacent normal tissues.
  • Achieving high tumor doses for local control is crucial but challenging with conventional external beam techniques.
  • Interstitial implantation provides a targeted approach to deliver high radiation doses directly to the tumor volume.

Purpose of the Study:

  • To evaluate the role and optimization of brachytherapy techniques in treating head and neck cancers.
  • To compare the efficacy and toxicity profiles of low dose rate (LDR) brachytherapy with emerging high dose rate (HDR) and pulsed dose rate (PDR) modalities.
  • To enhance the therapeutic ratio in head and neck tumor treatment through optimized brachytherapy strategies.

Main Methods:

  • Review of decades of clinical experience with interstitial brachytherapy for oral cavity, oropharyngeal, and nasopharyngeal carcinomas.
  • Analysis of large clinical series data to identify areas for optimization in low dose rate (LDR) brachytherapy.
  • Discussion of preliminary results from high dose rate (HDR) and pulsed dose rate (PDR) brachytherapy applications in head and neck cancer.

Main Results:

  • Interstitial brachytherapy allows for high tumor doses while sparing normal tissues, leading to improved local control.
  • Low dose rate (LDR) brachytherapy has a substantial track record in treating various head and neck cancers.
  • Emerging HDR and PDR brachytherapy techniques show promise in further refining treatment outcomes and potentially reducing complications.

Conclusions:

  • Interstitial brachytherapy is a valuable technique for maximizing tumor control and minimizing complications in head and neck cancer.
  • Optimization of LDR brachytherapy is necessary to improve the therapeutic ratio for these tumors.
  • HDR and PDR brachytherapy represent promising advancements that warrant further investigation and clinical adoption for head and neck malignancies.

Related Experiment Videos