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Updated: Oct 2, 2026

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat
Published on: November 21, 2025
Peripheral nerve blocks for postoperative analgesia
Jacqueline D Murauski1, Kathleen R Gonzalez
1Loyola University Health System, Maywood, Ill., USA.
Abstract:
Peripheral nerve blocks are used as part of a preemptive and multimodal analgesic technique to provide safe and effective postoperative pain management with minimal side effects. They are used for a variety of surgical procedures in both inpatient and outpatient settings. Peripheral nerve blocks have resulted in shorter recovery times, decreased anesthesia-related complications, and better postoperative pain management. Peripheral nerve blocks, as part of a multimodal analgesic regimen, have decreased recovery times by lessening side effects (e.g., nausea, vomiting, drowsiness). Nerve blocks have allowed procedures previously performed only in hospitals to be performed on an outpatient basis by providing extended surgical area analgesia. The use of peripheral nerve blocks, however, requires skilled and knowledgeable clinicians. This article discusses the mechanism of action and the role of peripheral nerve blocks in multimodal analgesia, as well as perioperative nursing implications and management for upper and lower extremity peripheral nerve blocks.
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