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Structural proteomics: developments in structure-to-function predictions
Martin Norin1, Michael Sundström
1Biovitrum, Department of Structural Chemistry., Stockholm, Sweden.
Trends in Biotechnology
|January 30, 2002
Summary
Post-genomic research faces challenges in assigning functions to novel genes and proteins. Structural proteomics aims to map all protein folds, aiding functional understanding by analyzing 3D structures.
Area of Science:
- Genomics
- Proteomics
- Structural Biology
Background:
- Post-genomic research requires functional assignment of numerous novel genes and proteins.
- Functional genomics approaches are crucial for data interpretation.
- Understanding protein 3D structures is key to functional assignment.
Purpose of the Study:
- To address the challenge of functional assignment in post-genomic research.
- To highlight the importance of 3D structural analysis for unassigned proteins.
- To describe the goals of structural proteomics in mapping protein structures.
Main Methods:
- Analysis of experimental and modeled 3D protein structures.
- Leveraging structural proteomics initiatives for data generation.
- Mapping the 'global proteome' by representing all protein folds.
Main Results:
- A significant number of novel proteins lack assigned functions.
- Current knowledge of 3D structural space is limited.
- Only a minority of the structural proteome has reliable template structures.
Conclusions:
- Functional assignment of novel proteins is a major post-genomic challenge.
- 3D structure analysis is essential for understanding protein function.
- Structural proteomics aims to comprehensively map protein structures to cover all folds.