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Related Experiment Videos

Albutensin A and complement C3a decrease food intake in mice.

Kousaku Ohinata1, Akio Inui, Akihiro Asakawa

  • 1Division of Food Bioscience and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, 611-0011, Kyoto, Japan.

Peptides
|January 30, 2002
PubMed
Summary
This summary is machine-generated.

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Albutensin A, a peptide from albumin, reduces food intake by acting on the complement C3a receptor, not the bombesin receptor. This peptide also affects gastric emptying and blood glucose levels.

Area of Science:

  • Biochemistry
  • Neuroendocrinology
  • Physiology

Background:

  • Serum albumin is a source of bioactive peptides.
  • Albutensin A is a peptide derived from serum albumin with potential physiological roles.
  • The mechanisms regulating food intake are complex and involve multiple signaling pathways.

Purpose of the Study:

  • To investigate the effects of Albutensin A on food intake, gastric emptying, and blood glucose levels.
  • To determine the receptor mediating the effects of Albutensin A on food intake.
  • To explore the role of complement C3a and C5a receptors in mediating Albutensin A's actions.

Main Methods:

  • Administration of Albutensin A and its analog Des-Arg-albutensin A via intracerebroventricular and peripheral routes in fasted mice.

Related Experiment Videos

  • Measurement of food intake, gastric emptying, and blood glucose levels.
  • Utilizing bombesin receptor knockout mice and investigating the role of complement C3a and C5a receptors.

    • Main Results:

    • Albutensin A dose-dependently decreased food intake and delayed gastric emptying, while elevating blood glucose.
    • The feeding inhibitory effect of Albutensin A was independent of the bombesin receptor.
    • Des-Arg-albutensin A did not inhibit food intake, suggesting involvement of C3a/C5a receptors.
    • Centrally administered C3a decreased food intake, whereas C5a increased it.
    • Albutensin A's effect on food intake was mediated through the C3a receptor.

    Conclusions:

    • Albutensin A inhibits food intake through the complement C3a receptor.
    • The findings elucidate a novel signaling pathway involving albumin-derived peptides and complement system in the regulation of appetite.