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Isolation of 3' -O-acetylchloramphenicol: a possible intermediate in chloramphenicol biosynthesis
Frank Gross1, Elizabeth A Lewis, Mahmood Piraee
1Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1.
Bioorganic & Medicinal Chemistry Letters
|January 30, 2002
Abstract:
3' -O-acetylchloramphenicol, commonly formed from chloramphenicol by resistant bacteria, has been isolated from the antibiotic-producing organism. Biosynthetic experiments suggest that it is a protected intermediate in chloramphenicol biosynthesis, implicating acetylation as a self-resistance mechanism in the producing organism.