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Tyrosylprotein sulfotransferase inhibitors generated by combinatorial target-guided ligand assembly
John W Kehoe1, Dustin J Maly, Dawn E Verdugo
1Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Bioorganic & Medicinal Chemistry Letters
|January 30, 2002
Abstract:
Tyrosylprotein sulfotransferases (TPSTs) catalyze the sulfation of tyrosine residues within secreted and membrane-bound proteins. The modification modulates protein-protein interactions in the extracellular environment. Here we use combinatorial target-guided ligand assembly to discover the first known inhibitors of human TPST-2.