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Updated: Oct 2, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Design, synthesis and biological activity of novel C2-C3' N-Linked macrocyclic taxoids
Iwao Ojima1, Xudong Geng, Songnian Lin
1Department of Chemistry, State University of New York at Stony Brook, NY 11794-3400, USA. iojima@notes.cc.sunysb.edu
Abstract:
A series of novel macrocyclic taxoids was designed and synthesized by connecting the C-2 and C-3' N positions of the taxoid framework with various tethers. Cytotoxicity of these macrocyclic taxoids was evaluated against a human breast cancer cell line LCC6-WT, and a couple of the taxoids exhibited 0.09-0.3 microM IC(50) values.
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