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Generation of a small library of cyclodepsipeptide PF1022A analogues using a cyclization-cleavage method with oxime
Byung H Lee1, Fred E Dutton, David P Thompson
1Discovery Research, Pharmacia Animal Health, Kalamazoo, MI 49001, USA. bhlee@pharmacia.com
Bioorganic & Medicinal Chemistry Letters
|January 30, 2002
Abstract:
N-Methyloctadepsipeptides attached to an oxime resin were cyclized by heating them in refluxing ethyl acetate for 2 days to give cyclodepsipeptide PF1022A analogues. By using this method, we generated a small library of PF 1022A analogues (2), several of which possessed anthelmintic activity, based on an in vitro assay.