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Binding of aminoglycoside antibiotics with modified A-site 16S rRNA construct containing non-nucleotide linkers
Jeffrey B-H Tok1, Wilson Wong, Nyla Baboolal
1Department of Chemistry & Natural Sciences, York College and Graduate Center of the City University of New York, 94-20 Guy R. Brewer Blvd., Jamaica, NY 11451, USA. tok@york.cuny.edu
Bioorganic & Medicinal Chemistry Letters
|January 30, 2002
Abstract:
The design and synthesis of synthetically modified cyclic A-site 16S rRNA construct is reported. The binding characteristics of several members of the aminoglycoside antibiotics with this novel class of synthetically modified A-site 16S rRNA constructs were subsequently investigated.