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New method of synthesis of Vinca alkaloid derivatives
Jacques Fahy1, Valérie Thillaye du Boullay, Dennis C H Bigg
1Division de Chimie Médicinale V, Centre de Recherche Pierre Fabre, 81106 Castres, France. jacques.fahy@pierre-fabre.com
Bioorganic & Medicinal Chemistry Letters
|January 30, 2002
Abstract:
Vinblastine and vinorelbine analogues have been synthesised by reacting new versatile electrophilic vindoline derivatives with various 3-substituted indoles. The resulting compounds have been evaluated for their antimitotic properties, but exhibited less potent activities in comparison with the standard binary Vinca alkaloids.