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Solid-phase synthesis of alpha-substituted 3-bisarylthio N-hydroxy propionamides as specific MMP inhibitors
Anne-Marie Chollet1, Thierry Le Diguarher, Nathalie Kucharczyk
1Institut de Recherches Servier, 125 chemin de Ronde, 78290 Croissy sur Seine, France.
Bioorganic & Medicinal Chemistry
|January 30, 2002
Abstract:
A novel series of potent and specific MMP-2,3,9,13 inhibitors has been obtained by modulation on solid phase by alpha and aryl substitutions on 3-arylthio-N-hydroxy-propionamides starting from itaconic acid.