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Enantioselective synthesis of (+)-4-demethoxy-1,4-dimethyldaunomycinone
Sambasivarao Kotha1, Richard J Stoodley
1Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai 400 076, India. srk@chem.iitb.ac.in
Bioorganic & Medicinal Chemistry
|January 30, 2002
Abstract:
(+)-4-Demethoxy-1,4-dimethyldaunomycinone 1 was synthesized using a convergent approach. Here, the key tetracyclic compound 10 was assembled by way of a Diels-Alder reaction using the sugar-based diene 8 and the quinizarin-related dienophile 7.