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[Sevoflurane in stop-flow interventions. Hemodynamics study].

A Di Filippo1, F Marini, M G Barneschi

  • 1Dipartimento Area Critica Medico-chirurgica, Sezione di Anestesia e Rianimazione, Università degli Studi, Firenze, Italy.

Minerva Anestesiologica
|January 30, 2002
PubMed
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Sevoflurane anesthesia maintained stable hemodynamics during stop-flow operations, a procedure involving regional perfusion for cancer treatment. This approach minimizes cardiocirculatory complications associated with the stop-flow technique.

Area of Science:

  • Oncology
  • Anesthesiology
  • Cardiovascular Physiology

Background:

  • Stop-flow operation involves locoregional perfusion with an antiblastic hypoxic solution for malignant tissue.
  • Cardiocirculatory complications like reduced cardiac index and increased pulmonary pressure are common.
  • Sevoflurane is utilized for its stable hemodynamic profile to mitigate these complications.

Purpose of the Study:

  • To evaluate the hemodynamic stability during stop-flow operations using Sevoflurane general anesthesia.
  • To assess the impact of Sevoflurane on cardiocirculatory parameters during this procedure.

Main Methods:

  • Six patients underwent stop-flow operations under general anesthesia with Sevoflurane (1 MAC in Air/O2).
  • Hemodynamic parameters including cardiac index, pressures, and saturation were recorded before, during, and after stop-flow.

Related Experiment Videos

  • Nitroglycerin infusion was used to maintain catheter balloon position.

    • Main Results:

    • During stop-flow, heart rate, cardiac index, and pulmonary capillary wedge pressure increased.
    • Mean arterial pressure, systemic vascular resistance, and pulmonary vascular resistance decreased during the procedure.
    • Post-reperfusion, most parameters normalized, with heart rate and central venous pressure tending to decrease.

    Conclusions:

    • General anesthesia with Sevoflurane demonstrates a stable hemodynamic profile during stop-flow operations.
    • Sevoflurane appears effective in managing cardiocirculatory challenges associated with this oncologic surgical technique.