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[Cryopreserved homografts in arterial reconstructions]
1Semmelweis Egyetem Altalános Orvostudományi Kar, Er- és Szívsebészeti Klinika, 1122 Budapest, Városmajor utca 68. birgab@kkt.sote.hu
Magyar Sebeszet
|January 31, 2002
Summary
Cryopreserved homologous vessels (CHV) offer a viable option for arterial reconstructions when autologous tissue is unavailable. This 4-year study highlights their use in complex cases, demonstrating crucial patency rates for vascular surgery.
Area of Science:
- Vascular Surgery
- Cryopreservation Biology
- Tissue Engineering
Context:
- Cryopreserved homologous vessels (CHV) serve as alternatives for arterial reconstruction when autologous options are unsuitable or prosthetic grafts are contraindicated.
- This study reviews four years of clinical experience with CHV in patients with aneurysms and lower limb obliterative arterial disease.
Purpose:
- To evaluate the efficacy and outcomes of using cryopreserved homologous vessels in arterial reconstructions.
- To assess graft and limb patency rates, complications, and mortality associated with CHV implantation.
Summary:
- Forty-four CHV grafts were implanted in 41 patients between 1997 and 2001, utilizing various venous and arterial segments.
- Grafts were cryopreserved using 10% DMSO and stored in liquid nitrogen, ensuring long-term availability.
- Postoperative outcomes included a 3-year graft patency of 23% and limb patency of 64% for infrainguinal reconstructions, with complications such as graft occlusion, reoperation, and limb amputation.
Impact:
- The findings suggest that CHV can be a suitable choice for vascular reconstruction in specific indications, particularly when biological material is essential.
- Understanding the outcomes and potential complications is vital for optimizing patient selection and surgical planning in vascular reconstruction procedures.