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Related Experiment Videos

Different risks for NSAID-induced anaphylaxis.

Eugène P van Puijenbroek1, Antoine C G Egberts, Ronald H B Meyboom

  • 1Netherlands Pharmacovigilance Foundation Lareb, Goudsbioemvallei 7, 's-Hertogenbosch, The Netherlands. e.vanPuijenbroek@Lareb.nl

The Annals of Pharmacotherapy
|January 31, 2002
PubMed
Summary

Nonsteroidal anti-inflammatory drugs (NSAIDs) are strongly linked to anaphylactic reactions. Diclofenac, ibuprofen, and naproxen show a disproportionately higher risk compared to other medications.

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Area of Science:

  • Pharmacovigilance
  • Drug Safety
  • Clinical Pharmacology

Background:

  • Spontaneous reporting systems are crucial for identifying adverse drug reactions post-marketing.
  • The Netherlands Pharmacovigilance Foundation Lareb has noted numerous anaphylactic reaction reports linked to nonsteroidal anti-inflammatory drugs (NSAIDs).

Purpose of the Study:

  • To determine if NSAIDs pose a higher risk for reported anaphylactic reactions compared to other drug classes.
  • To investigate potential differences in anaphylactic reaction risk among various NSAIDs.

Main Methods:

  • A case/noncase study design was employed.
  • Logistic regression analysis calculated reporting odds ratios (RORs).
  • Cases were defined as reports of anaphylactic or anaphylactoid reactions; noncases were all other reports. NSAID reports formed the index group.

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Main Results:

  • Between 1985 and 2000, 76 cases of anaphylactic reactions to NSAIDs were reported.
  • NSAIDs showed a strong association with anaphylactic reactions (adjusted ROR 9.4).
  • Diclofenac (ROR 17.2), naproxen (ROR 9.1), and ibuprofen (ROR 5.5) were disproportionately associated with anaphylactic reactions.

Conclusions:

  • This study reinforces findings of a relatively high risk of anaphylactic reactions with NSAID use.
  • Diclofenac, ibuprofen, and naproxen are specifically highlighted as posing a significant risk.